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Base editing in pigs for precision breeding

Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 161-170 doi: 10.15302/J-FASE-2019308

Abstract: Precision single base substitution provides a strategy for accurate genetic improvement in pig productionBase editing has recently been developed as the latest gene-editing tool that can directly make changesThis review summarizes gene-editing developments and highlights recent genetic dissection related toSNPs in major economic traits which may have the potential to be modified using SNP-editing applicationsIn addition, limitations and future directions of base editing in pig breeding are discussed.

Keywords： base editing     genetic improvement     pigs     single nucleotide polymorphisms    

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Base editing technology

Yidi SUN, Erwei ZUO, Hui YANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 227-228 doi: 10.15302/J-FASE-2020321

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Base editors: development and applications in biomedicine

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 359-387 doi: 10.1007/s11684-023-1013-y

Abstract: Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system with an individualdeaminase, enabling precise single-base substitution in DNA or RNA without generating a DNA double-strandBase editors offer more precise and secure genome-editing effects than other conventional artificialSince the development of the two main base editors, cytosine base editors (CBEs) and adenine base editors(ABEs), scientists have developed more than 100 optimized base editors with improved editing efficiency

Keywords： base editing     CBE     ABE     ADAR     DdCBE     disease model     therapeutic application    

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PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing Article

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Engineering 2022, Volume 15, Issue 8,   Pages 67-77 doi: 10.1016/j.eng.2022.02.013

Abstract: Clustered regularly interspaced short palindromic repeat (CRISPR) base editors allow for rapid, robust CRISPR associated protein 9 (St1Cas9) cytosine base editor (CBE)—but not the widely usededitors (CTBE and CGBE) capable of C-to-T or C-to-G conversions with dramatically enhanced editing productpurity and multiplexed editing capacity in Mycobacterium smegmatis (M. smegmatis).developed and characterized CTBE and CGBE in M. smegmatis, and then applied CTBE for genome editing

Keywords： CRISPR     Cas9     Mycobacterium tuberculosis     Genome editing     Base editing    

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Genome-edited crops: how to move them from laboratory to market

Kunling CHEN, Caixia GAO

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 181-187 doi: 10.15302/J-FASE-2020332

Abstract:

Recent breakthroughs in CRISPR technology allow specific genome manipulation of almost all crops and have initiated a revolution in precision crop breeding. Rationally-based regulation and widespread public acceptance are needed to propel genome-edited crops from laboratory to market and to translate this innovative technology into agricultural productivity.

Keywords： CRISPR/Cas     genome editing     base editing     precision breeding     regulation    

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Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 121-122 doi: 10.15302/J-FASE-2019317

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Search-and-replace editing of genetic information

Yao LIU, Xingxu HUANG, Xiaolong WANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 231-232 doi: 10.15302/J-FASE-2020322

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Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 148-160 doi: 10.15302/J-FASE-2019305

Abstract: Genome editing technology with its ability to directly introduce beneficial sequence variants offersHowever, embryo-mediated precision editing by homology-directed repair (HDR) mechanisms is currentlybreeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos.It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning withelite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism, enable multiplex editing

Keywords： animal breeding     cattle     cloning     CRISPR/Cas9     cytoplasmic injection     embryo     genome editing     germline chimaeras    

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A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 123-128 doi: 10.15302/J-FASE-2019309

Abstract:

The recent development of genome editing technologies has given researchers unprecedented power toThis mini-review briefly summarizes the development of major genome editing tools, focusing on the application

Keywords： animal model     CRISPR     genome editing     TALEN     ZFN    

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The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 171-180 doi: 10.15302/J-FASE-2019302

Abstract: However, new breeding methods combined with genome editing and somatic cell nuclear transfer or microinjectionRecent advances in precise genome editing technologies, especially clustered regularly interspaced shortand the state of the art and new insights into practical applications and social acceptance of genome editingconcluded that the production of gene-edited ruminants is feasible and through improvements in genome editing

Keywords： bioreactors     breeding     engineered endonucleases     genome editing     ruminants    

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Gene-editing in plants no longer requires tissue culture

Yi ZHANG, Michael PALMGREN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 229-230 doi: 10.15302/J-FASE-2020330

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GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

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Study of base friction simulation tests based on a complicated engineered bridge slope

Liu HE, Guang WU, Hua WANG

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 4,   Pages 393-397 doi: 10.1007/s11709-012-0174-6

Abstract: In this paper, a physical base friction test model of a slope is established.the slope in both its natural state and during excavation loading is qualitatively analyzed through baseThe base friction test results are then subjected to comparison and analysis using finite element numerical

Keywords： base friction test     slope stability evaluation     bridge slope    

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Livestock breeding for the 21st century: the promise of the editing revolution

Chris PROUDFOOT, Gus MCFARLANE, Bruce WHITELAW, Simon LILLICO

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 129-135 doi: 10.15302/J-FASE-2019304

Abstract: Genome editing provides the potential to move traits between breeds, in a single generation, with no

Keywords： cattle     pig     sheep     chicken     aquaculture     CRISPR    

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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 497-508 doi: 10.1007/s11684-017-0572-1

Abstract: Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeuticThis review discusses the recent advances of genome-editing tools for treating tumorigenic viruses andcorresponding cancers, the challenges that must be overcome before clinically applying such genome-editing

Keywords： genome-editing tools     tumorigenic virus     delivery method     off-target effect     virus-related carcinoma    

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Title Author Date Type Operation

Base editing in pigs for precision breeding

Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO

Journal Article

Base editing technology

Yidi SUN, Erwei ZUO, Hui YANG

Journal Article

Base editors: development and applications in biomedicine

Journal Article

PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Journal Article

Genome-edited crops: how to move them from laboratory to market

Kunling CHEN, Caixia GAO

Journal Article

Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Journal Article

Search-and-replace editing of genetic information

Yao LIU, Xingxu HUANG, Xiaolong WANG

Journal Article

Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Journal Article

A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Journal Article

The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Journal Article

Gene-editing in plants no longer requires tissue culture

Yi ZHANG, Michael PALMGREN

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

Study of base friction simulation tests based on a complicated engineered bridge slope

Liu HE, Guang WU, Hua WANG

Journal Article

Livestock breeding for the 21st century: the promise of the editing revolution

Chris PROUDFOOT, Gus MCFARLANE, Bruce WHITELAW, Simon LILLICO

Journal Article

Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Journal Article